abstract：:Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with myelodysplastic syndromes (MDS) and AML are rapidly evolving. A number of recent reports have identified better survival rates with intensive induction chemotherapy ...

journal_title：European journal of internal medicine

authors： Mueller BU,Seipel K,Pabst T

更新日期：2018-12-01 00:00:00

abstract：:Monoclonal gammopathy of unknown significance (MGUS) is the most frequent plasma cell disorder that commonly affects elderly patients. Although it is an asymptomatic condition, as well as smoldering myeloma (SMM), the risk of progression to multiple myeloma requiring therapy or other B-cell disorders varies greatly fo...

journal_title：European journal of internal medicine

authors： González-Calle V,Mateos MV

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:One of the major threats looming over the growing older population is frailty. It is a distinctive health state characterised by increased vulnerability to internal and external stressors. Although the presence of frailty is well acknowledged, its concept and operationalisation are hampered by the extraordin...

journal_title：European journal of internal medicine

authors： Junius-Walker U,Onder G,Soleymani D,Wiese B,Albaina O,Bernabei R,Marzetti E,ADVANTAGE JA WP4 group.

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state. METHODS:A total of 26,006 individuals seeking thalas...

journal_title：European journal of internal medicine

authors： Graffeo L,Vitrano A,Scondotto S,Dardanoni G,Pollina Addario WS,Giambona A,Sacco M,Di Maggio R,Renda D,Taormina F,Triveri A,Attanasio M,Gluud C,Maggio A

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Data on the prevalence of hepatitis C virus (HCV) infection in Italy are outdated and usually derived from studying residents in small towns. METHODS:To assess prevalence of and risk factors for HCV infection among Italian residents in 5 metropolitan areas, subjects ≥20 years of age were randomly selected f...

journal_title：European journal of internal medicine

authors： Andriulli A,Stroffolini T,Mariano A,Valvano MR,Grattagliano I,Ippolito AM,Grossi A,Brancaccio G,Coco C,Russello M,Smedile A,Petrini E,Martini S,Gaeta GB,Rizzetto M

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Renal dysfunction is associated with increased risk of mortality. The novel Full Age Spectrum (FAS) equations estimating the glomerular filtration rate (GFR) based on serum creatinine (FAScrea) and cystatin C (FAScysC) are validated across the entire age spectrum and are superior markers of renal function co...

journal_title：European journal of internal medicine

authors： Hojs Fabjan T,Penko M,Hojs R

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Early warning scores (EWS) have been developed to identify the degree of illness severity among acutely ill patients. One system, The Laboratory Decision Tree Early Warning Score (LDT-EWS) is wholly laboratory data based. Laboratory data was used in the development of a rare computerized method, developing...

journal_title：European journal of internal medicine

authors： Holm Atkins TE,Öhman MC,Brabrand M

更新日期：2018-05-01 00:00:00

abstract：:The endocannabinoid system is involved in many areas of physiological function and homeostasis. Cannabinoid receptors are expressed in the peripheral and central nervous system and on immune cells, all areas ideally suited to modulation of pain processing. There are a wealth of preclinical data in a number of acute, c...

journal_title：European journal of internal medicine

authors： Brown MRD,Farquhar-Smith WP

更新日期：2018-03-01 00:00:00

abstract：AIM:To assess whether in individuals aged 80years or older adherence to statins is accompanied by a reduced risk of all-cause mortality and major cardiovascular events. METHODS:A nested case-control study was carried out on a cohort of patients aged 80years or older (very elderly individuals), who were under treatment...

journal_title：European journal of internal medicine

authors： Corrao G,Monzio Compagnoni M,Franchi M,Cantarutti A,Pugni P,Merlino L,Catapano AL,Mancia G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Periodontal disease is prevalent in asthmatics, but it is unclear whether periodontal treatment plays a role in adverse respiratory events in these patients. We evaluated risk of hospitalization for adverse respiratory events (acute exacerbation, pneumonia, and acute respiratory failure) and mortality in ast...

journal_title：European journal of internal medicine

authors： Shen TC,Chang PY,Lin CL,Wei CC,Tu CY,Hsia TC,Shih CM,Hsu WH,Sung FC,Kao CH

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:18F-FDG PET/CT can detect large-vessel involvement in giant-cell arteritis (GCA) with a good sensitivity. In patients with clinically and biologically controlled disease, we aimed to assess how vascular uptakes evolve on repetitive FDG-PET/CT. PATIENTS AND METHODS:All included patients had to satisfy the 4 f...

journal_title：European journal of internal medicine

authors： de Boysson H,Aide N,Liozon E,Lambert M,Parienti JJ,Monteil J,Huglo D,Bienvenu B,Manrique A,Aouba A

更新日期：2017-12-01 00:00:00

abstract：AIMS:Abnormal sodium values are common among hospitalized patients. We aimed to investigate the association of admission sodium values and mortality. METHODS:Historical prospectively data of adult patients hospitalized to medical wards between January 2011 and December 2013. Admission sodium values were classified to ...

journal_title：European journal of internal medicine

authors： Akirov A,Diker-Cohen T,Steinmetz T,Amitai O,Shimon I

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Acute admissions to hospital are rising. As a part of a service evaluation we examined pathways of patients following hospital discharge depending on data available on admission to hospital. METHODS:We merged data available on admission to the Wrexham Maelor hospital from an existing data-base in the Acut...

journal_title：European journal of internal medicine

authors： Subbe CP,Goulden N,Mawdsley K,Smith R

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) with reduced ejection fraction remains a major therapeutic challenge. The aim of this study was to investigate the role of novel cardiovascular biomarkers, i.e. soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator ...

journal_title：European journal of internal medicine

authors： Lichtenauer M,Jirak P,Wernly B,Paar V,Rohm I,Jung C,Schernthaner C,Kraus J,Motloch LJ,Yilmaz A,Hoppe UC,Christian Schulze P,Kretzschmar D,Pistulli R

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The role of thrombophilic and cardiovascular risk factors in different manifestations of retinal vein occlusion (RVO), i.e., central or branch RVO, and at different ages is still debated. AIMS:To evaluate the association between thrombophilic and cardiovascular risk factors and the risk of RVO (overall, sep...

journal_title：European journal of internal medicine

authors： Bucciarelli P,Passamonti SM,Gianniello F,Artoni A,Martinelli I

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Prealbumin is a maker of nutritional status and inflammation of potential prognostic value in acute heart failure (HF). The aim of this study is to evaluate if low prealbumin levels on admission predict mortality and readmissions in patients with acute HF. METHOD:We conducted a prospective observational coh...

journal_title：European journal of internal medicine

authors： Franco J,Formiga F,Trullas JC,Salamanca Bautista P,Conde A,Manzano L,Quirós R,Franco ÁG,Ezquerro AM,Montero-Pérez-Barquero M,RICA investigators group.

更新日期：2017-09-01 00:00:00

abstract：:Diabetes mellitus type 2 (T2DM) has been associated with an increased cardiovascular risk. Improving glycaemia or other traditional cardiovascular risk factors may reduce cardiovascular risk in patients with T2DM. However, single risk intervention in T2DM has not provided convincing evidence in the reduction of cardio...

journal_title：European journal of internal medicine

authors： Burggraaf B,Castro Cabezas M

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. MATERIALS AND METHODS:388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arterie...

journal_title：European journal of internal medicine

authors： Fejer B,Tarnoki AD,Tarnoki DL,Lucatelli P,Littvay L,Maurovich-Horvat P,Jermendy AL,Kovacs A,Godor E,Fagnani C,Stazi MA,Molnar AA,Fanelli F,Cirelli C,Farina F,Baracchini C,Meneghetti G,Pucci G,Jermendy G,Merkely B,

更新日期：2017-06-01 00:00:00

abstract：AIM:To describe trends in the incidence and outcomes of community-acquired pneumonia (CAP) hospitalizations in Spain (2004-2013). METHODS:We used national hospital discharge data to select all hospital admissions for CAP as primary diagnosis. We analyzed incidence, Charlson comorbidity index (CCI), diagnostic and ther...

journal_title：European journal of internal medicine

authors： de Miguel-Díez J,Jiménez-García R,Hernández-Barrera V,Jiménez-Trujillo I,de Miguel-Yanes JM,Méndez-Bailón M,López-de-Andrés A

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The benefit of reducing the risk of stroke against increasing the risk of renal progression associated with antiplatelet therapy in patients with advanced chronic kidney disease (CKD) is controversial. METHODS:We enrolled 1301 adult patients with advanced CKD treated with erythropoiesis stimulating agents f...

journal_title：European journal of internal medicine

authors： Hsiao KC,Huang JY,Lee CT,Hung TW,Liaw YP,Chang HR

更新日期：2017-04-01 00:00:00

abstract：:Deprescribing can be defined as the process of withdrawal or dose reduction of medications which are considered inappropriate in an individual. The aim of this narrative review is to provide an overview of "deprescribing"; firstly discussing the potential benefits and harms followed by the barriers to and enablers of ...

journal_title：European journal of internal medicine

authors： Reeve E,Thompson W,Farrell B

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND & AIMS:Recently we have shown that cartilage oligomeric matrix protein (COMP), a fibrillar collagen assembly regulator, is strongly associated with cirrhosis and hepatocellular carcinoma progression. Therefore, we assessed whether serum COMP levels can be used as a non-invasive fibrosis marker in patients wi...

journal_title：European journal of internal medicine

authors： Zachou K,Gabeta S,Shums Z,Gatselis NK,Koukoulis GK,Norman GL,Dalekos GN

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Aspiration pneumonia (AP) is an infectious process causing high rates of mortality. The purpose of this study was: 1, to describe the incidence from 2003 to 2013 of AP hospitalizations; 2, to assess time trends in hospital outcomes variables, and; 3, to identify the factors independently associated with in-h...

journal_title：European journal of internal medicine

authors： Palacios-Ceña D,Hernández-Barrera V,López-de-Andrés A,Fernández-de-Las-Peñas C,Palacios-Ceña M,de Miguel-Díez J,Carrasco-Garrido P,Jiménez-García R

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:To describe trends in the rates and short-term outcomes of renal transplants (RTx) among patients with or without diabetes in Spain (2002-2013). METHODS:We used national hospital discharge data to select all hospital admissions for RTx. We divided the study period into four three-year periods. Rates were ca...

journal_title：European journal of internal medicine

authors： López-de-Andrés A,de Miguel-Yanes JM,Hernández-Barrera V,Méndez-Bailón M,González-Pascual M,de Miguel-Díez J,Salinero-Fort MA,Pérez-Farinós N,Jiménez-Trujillo I,Jiménez-García R

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:This work aims to evaluate the Minimum Basic Data Set (MBDS) as a data source in the detection of malignant tumors and explore its usefulness as a tool for epidemiological surveillance of cancer. MATERIALS AND METHODS:MBDS hospital data discharge from Prince of Asturias University Hospital (HUPA, Alcalá de H...

journal_title：European journal of internal medicine

authors： Fernández-Navarro P,López-Abente G,Salido-Campos C,Sanz-Anquela JM

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND AIM:Chronic kidney disease (CKD) and cardiovascular disease are closely interrelated and the presence of one condition synergistically affects the prognosis of the other, in a negative manner. There are surprisingly very few data on the relationship between baseline coronary artery disease (CAD) severity...

journal_title：European journal of internal medicine

authors： Turak O,Afsar B,Siriopol D,Yayla C,Oksuz F,Cagli K,Burlacu A,Covic A,Kanbay M

更新日期：2016-09-01 00:00:00

abstract：:Biologics embrace a wide range of substances synthesized by cells or living organisms by means of different biological processes, including recombinant DNA technology, controlled gene expression, or antibody technologies. A biosimilar establishes similarity to the reference medicinal product in terms of quality charac...

journal_title：European journal of internal medicine

authors： Pasina L,Casadei G,Nobili A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Nephropathia epidemica (NE), caused by Puumala virus (PUUV), is characterized by acute kidney injury (AKI) and thrombocytopenia. Cardiac involvement with electrocardiographic (ECG) abnormalities has been previously reported in NE; however, its prognostic value is unknown. Relative bradycardia is an important...

journal_title：European journal of internal medicine

authors： Kitterer D,Greulich S,Grün S,Segerer S,Mustonen J,Alscher MD,Braun N,Latus J

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The activation of complement system is associated with the development of hepatitis B virus-associated membranous nephropathy (HBV-MN) and heparin could inhibit the activation of complement system. METHODS:This was a three-center trial. Seventy-nine patients with HBV-MN participated in the study. The follow...

journal_title：European journal of internal medicine

authors： Yang Y,Ma L,Wang C,Kong D,Wang Y,Mei C

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Although experimental models have shown that statins could alleviate glomerular damage and decrease urinary protein excretion, the renal effects of statins remain unclear. A case-control study was conducted using data from Taiwan's National Health Insurance system. METHODS:An end-stage renal disease (ESRD) ...

journal_title：European journal of internal medicine

authors： Lin SY,Lin CL,Hsu WH,Lin CC,Chang CT,Kao CH

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:To compare serum vitamin D status in older inpatients with bullous pemphigoid (BP) and matched inpatients without BP, and to examine whether hypovitaminosis D, a high comorbidity burden or their combination were associated with BP. METHODS:This prospective case-control study was performed from November 2012...

journal_title：European journal of internal medicine

authors： Sarre ME,Annweiler C,Legrand E,Martin L,Beauchet O

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:In bromocriptine-treated hyperprolactinemic patients with impaired glucose tolerance, metformin was found to reduce plasma levels of prolactin. No previous study has investigated its impact on plasma prolactin in patients with drug-induced hyperprolactinemia. METHODS:The study included 20 women with antipsy...

journal_title：European journal of internal medicine

authors： Krysiak R,Kowalcze K,Szkrobka W,Okopien B

更新日期：2016-05-01 00:00:00

abstract：AIM:We investigated the association among long-term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPI use and increased risk of cardiovascular (CVD) morbidity in HD patients. METHODS:Of 418 HD patients that were screened ...

journal_title：European journal of internal medicine

authors： Mikolasevic I,Milic S,Stimac D,Zaputovic L,Lukenda Zanko V,Gulin T,Jakopcic I,Klaric D,Gulin M,Orlic L

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is a leading cause of long-term mortality after liver transplantation (LT). Life long immunosuppression harbors the risk of metabolic alterations. We aimed to analyze the impact of calcineurin (CNI)-only containing regimen (group A) compared to mTOR-containing regimen (group B) on lipi...

journal_title：European journal of internal medicine

authors： Zimmermann A,Zobeley C,Weber MM,Lang H,Galle PR,Zimmermann T

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Low serum levels of alkaline phosphatase (ALP) are a hallmark of hypophosphatasia. However, the clinical significance and the underlying genetics of low ALP in unselected populations are unclear. METHODS:In order to clarify this issue, we performed a clinical, biochemical and genetic study of 42 individuals...

journal_title：European journal of internal medicine

authors： Riancho-Zarrabeitia L,García-Unzueta M,Tenorio JA,Gómez-Gerique JA,Ruiz Pérez VL,Heath KE,Lapunzina P,Riancho JA

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:In discharged patients with heart failure (HF), diverse conditions can intervene to worsen outcome. We would investigate whether such factors present on hospital admission can affect long-term mortality in subjects hospitalized for acute HF. METHODS:One hundred twenty-three consecutive patients hospitalized...

journal_title：European journal of internal medicine

authors： Torres D,Cuttitta F,Paterna S,Garofano A,Conti G,Pinto A,Parrinello G

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Venous and arterial thrombosis share a number of pathogenic mechanisms, but the burden of pulmonary embolism (PE) has not been consistently compared with that in other arterial diseases. METHODS:We used the Spanish National Discharge Database to compare the frequency, clinical characteristics and mortality ...

journal_title：European journal of internal medicine

authors： Guijarro R,de Miguel-Diez J,Jimenez D,Trujillo-Santos J,Otero R,Barba R,Monreal M

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Patients with non-transfusion-dependent thalassemia (NTDT) present with a spectrum of disease severities. Since there are multiple pathophysiologies in such patients, tailoring treatment remains essential. Therefore, one simple, reliable tool would be beneficial to assess disease severity and tailor therapy,...

journal_title：European journal of internal medicine

authors： Cappellini MD,Porter JB,Musallam KM,Kattamis A,Viprakasit V,Galanello R,Taher AT

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The site of acquisition of infection may have a major impact on outcome. The health care-related (HCR) environment has recently come under scrutiny. In a group of patients with bacteremic septic arthritis (SA), we compared their characteristics, type of SA, microbiology and prognosis according to the site of...

journal_title：European journal of internal medicine

authors： Murillo O,Gomez-Junyent J,Grau I,Ribera A,Cabrera C,Pedrero S,Tubau F,Nolla JM,Ariza J,Pallares R

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The association between exacerbation of heart failure (HF) and use of non-steroidal anti-inflammatory drugs (NSAIDs) has long been recognized but the data on this adverse effect are limited. METHODS:To further characterize this possible association, we conducted a systematic review and meta-analysis of obse...

journal_title：European journal of internal medicine

authors： Ungprasert P,Srivali N,Kittanamongkolchai W

更新日期：2015-11-01 00:00:00